Jinan Jianfeng Chemical Co., Ltd. is an enterprise specialized in the production of pharmaceutical raw materials and Intermediates, which integrates scientific research, production and sales. Relying on the management concept of "people-oriented, science and technology leading", Jinan Jianfeng Chemical Co., Ltd. has gathered a large number of cutting-edge talents in related industries. Guided by the development trend of world pharmaceutical and chemical industry, it continuously develops superior varieties at home and abroad. Its products are based on C. P, USP, EP, JP and other standards produce high-quality products, and sold to the United States, Germany, Canada, Japan, Russia, Brazil and more than thirty countries.
Amitriptyline hydrochloride is a kind of dibenzocycloheptene-derivative tricyclic antidepressant(TCA) and analgesic. The TCAs has similar structure with phenothiazines, containing a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs take effect through acting as potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs such as amitriptyline has a more potent inhibitory effect on serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs can also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs might be related to the overall increase in serotonergic neurotransmission. In addition, TCAs can also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).
Amitriptyline was one of the first successful antidepressants developed and has been widely used for the treatment of depression since the early 1960s. As early as in 1964, Lance and Curran reported that amitriptyline was effective in tension-type headache independent of the antidepressant effect and a positive effect in migraine was reported in 1973 . Thus, amitriptyline is an old, well-known drug not only for the treatment of depression but also for primary headaches. The chemical structure of the tricyclic antidepressant, amitriptyline, is shown in FIGURE 1.
The other name of the product is Amitriptyline hydrochloride Dose,Cas 549-18-8 Uses,Reviews Cas 549-18-8 Uses.
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