Dabigatron ester is another new oral anticoagulant drug approved by the Food and Drug Administration of the United States after warfarin. It is a non-peptide thrombin inhibitor and exerts anticoagulant effect by specifically and selectively blocking the activity of thrombin (free or binding). It is an important progress in the field of anticoagulation therapy and potential lethal thromboprophylaxis, and has milestone significance. After oral administration through the gastrointestinal tract, it is converted into a group of dabiga with direct anticoagulant activity in vivo. By binding to fibrin specific binding sites of thrombin, fibrinogen is prevented from splitting into fibrin, thus blocking the final steps of the clotting waterfall network and thrombosis. It can also dissociate from fibrin-thrombin conjugates and play a reversible anticoagulant role.
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