Febuxostat is a new generation of xanthine oxidase inhibitors developed by Emperor Company of Japan. It is clinically used to treat hyperuricemia (gout). Its structure is completely different from that of xanthine oxidase inhibitors developed 40 years ago. It is a new and highly effective non-purine xanthine oxidase selective inhibitor. Xanthine oxidase is the key enzyme to promote the production of uric acid. Febusotan can reduce the level of uric acid in blood of patients with hyperuricemia and gout. Clinical studies have shown that it is safe and effective. It is metabolized through the liver and does not depend on the excretion of the kidney. Therefore, it is not necessary to reduce the dose in patients with moderate to severe hepatorenal insufficiency. The dosage is 40 mg or 80 mg once a day. It is not recommended to treat gout patients without hyperuricemia.
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