Tianeptine has antidepressant and anxiolytic effects. We are manufacturer of the product. Tianeptine, was discovered and patented by the French Society of Medical Research in the 1960s, sold under the brand names Stablon and Coaxil among others, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder. Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors, are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown mechanism of action. It may also be used to treat anxiety, asthma, and irritable bowel syndrome. You can check tianeptine reddit on reddit. Moreover, tianeptine has been shown to be effective in preventing alcohol intake in alcoholics suffering from depression.
Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects.
Tianeptine is a selective serotonin reuptake enhancer that is not available in the US. No clinically meaningful changes relative to placebo were observed in a 12 week, placebo-controlled, cross-over study of tianeptine (Niederhofer, Staffen, & Mair, 2003).
Antidepressants are, almost by definition, cognitive enhancers. The antidepressant action of drugs such as tianeptine is increasingly recognized as being mediated in part by promotion of synaptic plasticity and growth (Zhang et al., 2013). This is supported by a strong association between depression and Alzheimer`s disease, for which the earliest effect is a loss of synapses.
Tianeptineis a generally well-tolerated medication which, like the SSRIs, has both antidepressant and anxiolytic activity. Preclinical work suggests that tianeptine has neuroprotective effects against stress-induced dendritic atrophy in the hippocampus, and has neurogenic actions (Kasper & McEwen, 2008) and might engender these effects via modulation of glutamate neurotransmission (Zoladz, Park, Muñoz, Fleshner, & Diamond, 2008).
We recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR). Here we demonstrate that the acute and chronic antidepressant-like behavioral effects of tianeptine in mice require MOR. The other names are Tianeptine Free Acid Cas 66981-73-5, Tianeptine Sodium Pills, and Tianeptine Free Acid White Powder.
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