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Imatinib Mesilate CAS922-32-7 CML

    Unit Price: USD 2.2 - 2201 / Gram
    Payment Type: L/C,D/P,Paypal,Western Union
    Incoterm: FOB,CIF,EXW
    Min. Order: 1 Gram
    Delivery Time: 7 Days
Basic Info

Model No.:  CAS922-32-7

Function: Disinfectant and Preservatives, Respiratory System Agents, Cardiovascular Agents, Drug Treatment of Mental Disorder, Blood System Agents, Anesthetic and Adjuvant, Antiparasitic, Vitamins and Minerals Deficiency Drug

Certification: FDA, SGS, Reach

Type: Analysis reagent, Auxiliaries And Other Medicinal Chemical

State: Solid

Grade Standard: Cosmetic Grade

Volatile: Not Volatile

Appearance: White Crystal

Melting Point: 62-67℃

Insoluble Substance: ≤0.02%

Residue On Ignition: Conforms

Water: 0.1%

Purity: 98.28%

Shelf Life: 3 Years

Brand Name: JF

IR: Comforms

Additional Info

Packaging: Antidepressant tianeptine sodium powder 30123-17-2 for bag or drum

Productivity: 2000kg

Brand: Jianfeng

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 2000kg

Certificate: ISO90011

HS Code: 29349990.99

Port: QingDao,ShangHai,Guangzhou

Product Description

Acute lymphoblastic leukemia in adults and children that is Philadelphia chromosome positive In adults, it is used for disease that has recurred (come back) or is refractory (does not respond to treatment). In children, it is used as the first treatment after the disease is diagnosed. Imatinib was launched as Gleevec in the US for chronic myelogenous leukemia (CML) in blast crisis, accelerated phase or chronic phase after interferon-alpha failure. This compound can be prepared by a four step sequence from a condensation of the 1-(3-pyridyl)ethanone with dimethyl formamide dimethylacetal, followed by successive cyclization with the methyl-nitrophenyl guanidine, hydrogenolysis and condensation with the benzoyl chloride of the methylpiperazine. Imatinib is the first of a new class of anticancer drugs that are specifically designed to target the molecular pathways involved (oncogenic event) in the development of disease. The Brc-Abl oncoprotein is a constitutively active tyrosine kinase that causes CML. Imatinib is a competitive inhibitor of this tyrosine kinase as well as Abl, Kit and the PDGFR kinases It binds to the ATP-binding site of the target kinase and prevents the transfer of phosphate from ATP to the tyrosine residues of various substrates and consequently blocks the proliferation of the leukemic cells.

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The other name of this product: Glivec; gleevec;imatinib methanesulfonate;imatinib mesilate; 4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide methanesulfonate; 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate; Imatinibmesylate; Imatinib Mesylate(Alpha form).

Looking for ideal CML Chronic Myelogenous Leukemia Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the GIST Imatinib Mesilate are quality guaranteed. We are China Origin Factory of Cancer Tyrosine Kinase. If you have any question, please feel free to contact us.

Product Categories : Anticancer/Antitumor/Antineoplastic

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