Chemical Name: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
Molecular Formula: C13H10BrCl2FN2O
Formula Weight: 380
CAS No.: 877399-00-3
Chemical Name: Crizotinib
Molecular Formula: C21H22Cl2FN5O
Formula Weight: 450.343
CAS No.: 877399-52-5
Crizotinib is an oral receptor tyrosine kinase inhibitor. The molecular formula for crizotinib is C21H22Cl2FN5O. The molecular weight is 450.34 Daltons
Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.
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