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Imatinib Mesilate api cas 220127-57-1 cas 152459-95-5

Basic Info

Function: Antineoplastic

Grade Standard: Medicine Grade

Type: Chemical Reagent

State: Solid

Volatile: Not Volatile

Product Description
Chemical Name: Imatinib
Molecular Formula: C29H31N7O
Formula Weight: 493.6
CAS No.: 152459-95-5


Product Name: Imatinib Mesilate

CAS NO: 220127-57-1

Standard: Enterprise Standard

Molecular Formula: C30H35N7O4S

Molecular Weight : 589.71

Description: White crystal or crystalline powder

Package :25KG/drums

Chemical names, synonyms:


4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate, STI-571, IMATINIB BASE(IMA-3), Imatinib (STI-571) Mesylate



Minimum purity: 99%

Imatinib Mesilate 220127-57-1

Description

White to off-white Crystalline Powder

Identification By IR

IR spectrum of the sample should concordant to the standard spectrum.

Solubility

Soluble in Water

LOD

NMT 0.5% w/w

Related substance

by HPLC

Single Max. Imp : NMT 0.1 %

Total Max Imp : NMT 1.0 %

Assay (By HPLC)

NMT 98.0% And NLT 102 %

ROI

NMT 0.5%

Heavy metals

NMT 0.5%

Thermo gram

220-227ºC

Imatinib Mesylate is a targeted therapy. Imatinib Mesylate is classified as a signal transduction inhibitor - protein-tyrosine kinase inhibitor.

A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.

Imatinib mesylate (also called Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia.

As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans.



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